Exosomes‐Loaded Electroconductive Hydrogel Synergistically Promotes Tissue Repair after Spinal Cord Injury via Immunoregulation and Enhancement of Myelinated Axon Growth
South China University of Technology · First Affiliated Hospital Zhejiang University · +13 more institutions
Abstract
Electroconductive hydrogels are very attractive candidates for accelerated spinal cord injury (SCI) repair because they match the electrical and mechanical properties of neural tissue. However, electroconductive hydrogel implantation can potentially aggravate inflammation, and hinder its repair efficacy. Bone marrow stem cell-derived exosomes (BMSC-exosomes) have shown immunomodulatory and tissue regeneration effects, therefore, neural tissue-like electroconductive hydrogels loaded with BMSC-exosomes are developed for the synergistic treatment of SCI. These exosomes-loaded electroconductive hydrogels modulate microglial M2 polarization via the NF-κB pathway, and synergistically enhance neuronal and…
Citation impact
- FWCI
- 50.06
- Percentile
- 100%
- References
- 61
Authors
16- LFLei Fan
South China University of Technology
- CLCan Liu
First Affiliated Hospital Zhejiang University, Zhejiang University
- XCXiuxing Chen
Sun Yat-sen University, Sun Yat-sen Memorial Hospital
- LZLei Zheng
Nanfang Hospital, Southern Medical University
- YZYan Zou
Sun Yat-sen University, Third Affiliated Hospital of Sun Yat-sen University
Topics & keywords
- Microvesicles
- Axon
- Spinal cord injury
- Spinal cord
- Cell biology
- Chemistry
- Neuroscience
- Biology
- Good health and well-being