Safety of the oral factor XIa inhibitor asundexian compared with apixaban in patients with atrial fibrillation (PACIFIC-AF): a multicentre, randomised, double-blind, double-dummy, dose-finding phase 2 study

Piccini, Jonathan P.; Caso, Valeria; Connolly, Stuart J.; Fox, Keith A.A.; Oldgren, Jonas; Jones, W. Schuyler; Gorog, Diana A.; Durdil, Václav; Viethen, Thomas; Neumann, Christoph; Mundl, Hardi; Patel, Manesh R.; Auer, Johann; Hubauer, Martin; Pandzic, Sead; Preishuber, Eva; Primus-Grabscheit, Carina; Reitgruber, Dietmar; Schmalzer, Florian; Adlbrecht, Christopher; Schober, Andreas; Hajos, Johannes; Keil, Christoph; Schratter, Alexandra; Frick, Matthias; Benda, Magdalena; Mächler, Maximilian; Mutschlechner, Beatrix; Saely, Christoph H.; Sprenger, Lukas; Lichtenauer, Michael; Eber, Miriam; Hoppe, Uta C.; Kolbitsch, Tobias; Jirak, Peter; Mirna, Moritz; Schönbauer, Robert; Bergler‐Klein, Jutta; Hengstenberg, Christian; Stojković, Stefan; Scherr, Daniel; Manninger-Wünscher, Martin; Rohrer, Ursula; Stühlinger, Markus; Schgoer, Wilfried; Schwarzl, Jana M.; Pürerfellner, Helmut; Derndorfer, Michael; Ebner, Christian; Eder, Veronika; Κόλλιας, Γεώργιος; Sturmberger, Thomas; Sieghartsleitner, Stefan; Vijgen, Johan; Koopman, Peter; Dujardin, Karl; Anné, Wim; Ceuninck, Michel De; Tavernier, René; Duytschaever, Mattias; Knecht, Sébastien; Missault, Luc; Vandekerckhove, Yves; Rossenbacker, Tom; Ector, Bavo; Charlier, Filip; Debruyne, Philippe; Dewilde, Willem; Janssens, Luc; Roosen, John; Vankelecom, Bart; Heidbüchel, Hein; Delesie, Michiel; Vervoort, G. M. M.; Rombouts, Hans; Vanassche, Thomas; Engelen, Matthias M.; Verhamme, Peter; Willems, Rik; Constance, Christian; Pranno, Nicolas; Cox, Jafna L.; Bata, Iqbal; Macle, Laurent; Aguilar, Martín; Tourigny, J.; Dubuc, Marc; Dyrda, Katia; Guerra, Peter G.; Khairy, Paul; Mondésert, Blandine; Rivard, Léna; Roy, Denis; Tadros, Rafik; Talajic, Mario; Thibault, Bernard; Nault, Isabelle; Blier, L.; Champagne, Jean; Molin, Franck; O’Hara, Gilles; Philippon, François; Plourde, Benoît; Sarrazin, J.; Steinberg, Christian E. W.; Coufal, Zdeněk; Balazsik, David; Mikulica, M; Zápeca, Jakub; Čermák, Ondřej; Drasnar, Tomas; Falc, Matej; Hornof, Josef; Racz, Blazej; Weissova, Danica; Línková, Hana; Pašková, Eva; Petr, Robért; Širáková, Andrea; Kettner, Jiří; Benak, Ales; Holek, Martin; Podpera, Ivo; Podperova, Monika; Vančura, V.; Jandik, Tomas; Šmı́d, Jiřı́; Dedek, Vratislav; Banik, J.; Durdil, Václav; Hnát, Tomáš; Lellouche, Nicolas; Rouffiac, Ségolène; Taldir, Guillaume; Bridonneau, Valentin; Couffon, Philippe; Daudin, M.; Hamon, Cécile; Lacaze, Jonathan; Quentin, A; Thébault, Christophe; Boiffard, Emmanuel; Billon, Olivier; Miette, Fabien; Pouliquen, Hervé; Turlotte, Guillaume; Gorka, Hervé; Albert, Franck; Bayle, Sandrine; Bensaid, R.; Dasoveanu, Madalina; Demichili, Thibaud; Dutoiu, Téodora; Khalil, Cliff; Loghin, Caterina; Rangé, Grégoire; Roussel, Laurent; Socié, Pierre; Thuaire, Christophe; Extramiana, Fabrice; Algalarrondo, Vincent; Boughanmi, Haten; Mansour, Noreddine El; Mohammad, Usman; Sellier, Romain; Elbaz, Meyer; Laperche, Clémence; Maury, Philippe; Kiss, Róbert Gábor; Borsányi, Tünde; Gingl, Zoltán; Polgar, Balaza; Benczúr, Béla; Bodor, A.; Hepp, Tamas; Maláti, Éva; Nagy, László; Erdei, Norbert; Kapus, Jozsef; Kapus, Katalin; Tóth, Brigitta; Matoltsy, Andras; Kiss, Tunde; Merkely, Béla; Herczeg, Szilvia; Kiss, Orsolya; Salló, Zoltán; Tóth, Kálmán; Habon, Tamás; Rábai, Miklós; Tótsimon, Kinga; Zilahi, Z; Bencze, G.; Sánta, János; Aradi, Dániel; Kelemen, Barbara; Bolognese, Leonardo; Nesti, Martina; Notarstefano, Pasquale; D’Orazio, Simona; Cosmi, Franco; Becattini, Cecilia; Agnelli, Giancarlo; Broccatelli, Belinda; Mosconi, Maria Giulia; Paciaroni, Maurizio; Urbini, Chiara; Parato, Vito Maurizio; Notaristefani, Camilla; Scarano, Michele; Ameri, Pietro; Ghigliotti, G.; Guglielmi, Giulia; Lotti, Roberta; Merlo, Andrea; Muiesan, María Lorenza; Abondio, Andrea; Berasi, Caterina; Mattiuzzo, Elena; Mutti, Claudio; Salvetti, Massimo; Pignatelli, Pasquale; Menichelli, Danilo; Pastori, Daniele; Tamiya, Eiji; Μatsumoto, Takahiro; Takabe, Tomosato; Yamamoto, Shoichi; Yamashita, Haruyo; Higashiue, Shinichi; Furuya, Onichi; Hiramatsu, Norihiko; Kasuga, Kensuke; Kojima, Saburo; Komooka, Masatoshi; Kuroyanagi, Satoshi; Matsuura, Makoto; Takemoto, Tetsushi; Yamamoto, Shuji; Saito, Katusmi; Abe, Takuro; Ishida, Issei; Iwanami, Yuji; Kataoka, Shohei; Moriyama, Tetsu; Murohashi, Akira; Sasaki, Akihito; Nakamura, Yuichiro; Ueno, Tetsuya; Shimane, Akira; Hamana, Tomoyo; Ichibori, Hirotoshi; Inoue, Tomohiro; Itoh, Mitsuaki; Iwane, Seigo; Kawai, Hiroya; Kokawa, Tatsuya; Masumoto, Akiko; Matsuo, Koki; Miyata, Taishi; Nakano, Shinsuke; Oishi, Shogo; Onishi, Tetsuari; Sawada, Takahiro; Saito, Takayuki; Shoda, Mitsuhiko; Takahashi, Nobuyuki; Takaya, Tomofumi; Taniguchi, Yasuyo; Tsukamoto, Shota; Tsukishiro, Yasue; Tsukiyama, Yoshiro; Tsunamoto, Hiroshi; Uzu, Kenzo; Yamamoto, Hiroyuki; Yamamoto, Tetsuya; Yokoi, Kiminobu; Yoshida, Chiaki; Watanabe, Nobuhiro; Betsuyaku, Tetsuo; Adachi, Kumiko; Awane, Kouichi; Goto, Daisuke; Sakakibara, Mamoru; Watanabe, Masashi; Ueno, Hideki; Hiroe, Yoshitaka; Matsuo, Koshi; Ayata, K.; Fukuda, Ko; Hata, Yoshiki; Hashimoto, Katsushi; Matsumi, Hiroaki; Nikaido, Akira; Okamoto, Shuichi; Sime, Iveta; Stirna, V; Reinholde, Ilze; Hansone, Silvija; Kozlovska, Anita; Romanova, Janina; Klincare, Dace; Pontaga, Natalja; Dirmans, Igors; Kalniņš, Artis; Upīte, Dana; Gersamija, A.; Teleznikovs, Arturs; Rozkova, Nadezda; Safro, Jelena; Camós, Ignasi Anguera; Dallaglio, Paolo; Salguero‐Bodes, Rafael; Arnbas, Fernando; Borrego, Luís Miguel; Marco, Álvaro; Jiménez, Javier Ramos; Gómez‐Doblas, Juan José; Cabeza, Alejandro Pérez; González, Ignacio Ferreira; Freire, Javier Limeres; López-Grau, Mercè; Prat, Xavier Viñolas; Weidmann, Zoraida Moreno; Ramos, Jose Maria Guerra; Martin, Maria Concepcion Alonso; Campos, Bieito; Carranza, Javier Mauricio Mogro; Zurita, Francisco Javier Méndez; Font, Enrique Rodríguez; Matos, Carlos Eduardo Gonzales; Hernando, Víctor; Lindholm, Carl-Johan; Thulin, Jörgen; Wallén, Håkan; Hagwall, Kristina; Eliasson, Ken; Lundvall, Martin; Olsson, Jens; Kjellman, B; Lind, Markus; Johansson, Lars; Svedberg, Niclas; Berglund, Stefan; Söderberg, Julia; Zedigh, C.; Mooe, Thomas; Axelsson, Mattias; Binsell, Emil; Huber, Daniel; Müller, Christian; Danier, Isabelle; Kühne, Michael; Okamura, Bernhard; Schoepfer, Hadrien; Simmen, Cornelia; Reichlin, Tobias; Chollet, Laurève; Lam, Anna; Wittmer, Severin; Rickli, Hans; Gall, C.; Hametner, Greta; Intorp, Stephanie; Luescher, Daniel; Haegeli, Laurent; Berg, Jan Christopher; Ebrahimi, Ramin; Auricchio, Angelo; Crljenica, Carmela; Moccetti, T; Monti, Cristina; Pasotti, Elena; Petrova, Iveta; Rossi, Mariagrazia; Mach, François; Namdar, Mehdi; Groot, Joris de; Proost, Virginnio; Neefs, Joline; Linz, Dominik; Stipdonk, Twan van; Uijl, Dennis W. den; Alings, Marco; Schaap, Jeroen; Segers, Dolf; Wouters, Noëmi T.A.E.; Bartels, Louis; Tieleman, Robert G; Pisters, Ron; Vries, Tim de; Selig, Jaap; Kuijper, Aaf F.M.; Bot, Pieter T.; Keijzers, Mitran; Verdel, Gerardus; Tukkie, Raymond; Bos, Ewout van den; Kauer, Floris; Oemrawsingh, Rohit M.; Stevenhagen, J.; Es, Jan van; Lip, Gregory Y.H.; Gupta, Dhiraj; Kotalczyk, Agnieszka; Gunstone, Anthony; Brixey, Richard David; Gorog, Diana A.; Dinarvand, Danial; Gue, Ying X.; Kanji, Rahim; Memtsas, Vassilios; Senior, Roxy; Bioh, Gabriel; Wong, Yuk-ki; Child, Nick

doi:10.1016/s0140-6736(22)00456-1

articleThe LancetApr 1, 2022BRONZE OA

Safety of the oral factor XIa inhibitor asundexian compared with apixaban in patients with atrial fibrillation (PACIFIC-AF): a multicentre, randomised, double-blind, double-dummy, dose-finding phase 2 study

JPJonathan P. Piccini VCValeria Caso SJStuart J. Connolly KAKeith A.A. Fox JOJonas Oldgren

Duke University · Clinical Research Institute · +13 more institutions

PubMed

Indexed incrossrefpubmed

Abstract

No abstract available for this paper.

Citation impact

307

total citations

FWCI: 43.76
Percentile: 100%
References: 24

Citations per year

Authors

416

JP
Jonathan P. PicciniCorresponding
Duke University, Clinical Research Institute, Duke Medical Center
VC
Valeria Caso
University of Perugia
SJ
Stuart J. Connolly
Population Health Research Institute, Hamilton Health Sciences, McMaster University
KA
Keith A.A. Fox
University of Edinburgh
JO
Jonas Oldgren
Uppsala University

Topics & keywords

Topics

Coagulation, Bradykinin, Polyphosphates, and Angioedema99%
Atrial Fibrillation Management and Outcomes0%
Blood Coagulation and Thrombosis Mechanisms0%

Keywords

Apixaban
Atrial fibrillation
Medicine
Double blind
Internal medicine
Cardiology
Gastroenterology
Surgery

UN Sustainable Development Goals

Good health and well-being

No related works found for this paper.

Funding

B
Bayer