reviewSignal Transduction and Targeted TherapyApr 13, 2022GOLD OA

Targeting non-coding RNAs to overcome cancer therapy resistance

BCBaoqing ChenMPMihnea P. DragomirYCYang ChenQLQiaoqiao LiDHDavid Horst

Sun Yat-sen University · Sun Yat-sen University Cancer Center · +7 more institutions

PubMed
Indexed incrossrefdoajpubmed

Abstract

It is now well known that non-coding RNAs (ncRNAs), rather than protein-coding transcripts, are the preponderant RNA transcripts. NcRNAs, particularly microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs), are widely appreciated as pervasive regulators of multiple cancer hallmarks such as proliferation, apoptosis, invasion, metastasis, and genomic instability. Despite recent discoveries in cancer therapy, resistance to chemotherapy, radiotherapy, targeted therapy, and immunotherapy continue to be a major setback. Recent studies have shown that ncRNAs also play a major role in resistance to different cancer therapies by rewiring essential signaling pathways. In this review, we present…

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419
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37.65
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100%
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Authors

6

Topics & keywords

Topics
Keywords
  • microRNA
  • Non-coding RNA
  • Biology
  • Cancer
  • Long non-coding RNA
  • Computational biology
  • RNA
  • Bioinformatics
UN Sustainable Development Goals
  • Good health and well-being
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