Engineering strategies to enhance oncolytic viruses in cancer immunotherapy
Sichuan University · Sichuan University of Science and Engineering
Abstract
Oncolytic viruses (OVs) are emerging as potentially useful platforms in treatment methods for patients with tumors. They preferentially target and kill tumor cells, leaving healthy cells unharmed. In addition to direct oncolysis, the essential and attractive aspect of oncolytic virotherapy is based on the intrinsic induction of both innate and adaptive immune responses. To further augment this efficacious response, OVs have been genetically engineered to express immune regulators that enhance or restore antitumor immunity. Recently, combinations of OVs with other immunotherapies, such as immune checkpoint inhibitors (ICIs), chimeric antigen receptors (CARs), antigen-specific T-cell receptors (TCRs) and…
Citation impact
- FWCI
- 45.86
- Percentile
- 100%
- References
- 365
Authors
3Topics & keywords
- Oncolytic virus
- Virotherapy
- Immunotherapy
- Chimeric antigen receptor
- Immune system
- Cancer immunotherapy
- Antigen
- Acquired immune system
- Good health and well-being