Adipose tissue aging: mechanisms and therapeutic implications
Shanghai Jiao Tong University · Shanghai Ninth People's Hospital
Abstract
Adipose tissue, which is the crucial energy reservoir and endocrine organ for the maintenance of systemic glucose, lipid, and energy homeostasis, undergoes significant changes during aging. These changes cause physiological declines and age-related disease in the elderly population. Here, we review the age-related changes in adipose tissue at multiple levels and highlight the underlying mechanisms regulating the aging process. We also discuss the pathogenic pathways of age-related fat dysfunctions and their systemic negative consequences, such as dyslipidemia, chronic general inflammation, insulin resistance, and type 2 diabetes (T2D). Age-related changes in adipose tissue involve redistribution of deposits…
Citation impact
- FWCI
- 27.30
- Percentile
- 100%
- References
- 161
Authors
5- MOMin‐Yi OuCorresponding
Shanghai Jiao Tong University, Shanghai Ninth People's Hospital
- HZHao Zhang
Shanghai Jiao Tong University, Shanghai Ninth People's Hospital
- PTPoh‐Ching Tan
Shanghai Jiao Tong University, Shanghai Ninth People's Hospital
- SZShuang‐Bai Zhou
Shanghai Jiao Tong University, Shanghai Ninth People's Hospital
- QLQingfeng Li
Shanghai Jiao Tong University, Shanghai Ninth People's Hospital
Topics & keywords
- Adipose tissue
- Insulin resistance
- Biology
- Inflammation
- Endocrinology
- Internal medicine
- Medicine
- Diabetes mellitus