Symptom burden and health-related quality of life in chronic kidney disease: A global systematic review and meta-analysis

BACKGROUND: The importance of patient-reported outcome measurement in chronic kidney disease (CKD) populations has been established. However, there remains a lack of research that has synthesised data around CKD-specific symptom and health-related quality of life (HRQOL) burden globally, to inform focused measurement of the most relevant patient-important information in a way that minimises patient burden. The aim of this review was to synthesise symptom prevalence/severity and HRQOL data across the following CKD clinical groups globally: (1) stage 1-5 and not on renal replacement therapy (RRT), (2) receiving dialysis, or (3) in receipt of a kidney transplant. METHODS AND FINDINGS: MEDLINE, PsycINFO, and…

• GS
  Gilead Sciences
• PO
  Patient-Centered Outcomes Research Institute
• MC
  Macmillan Cancer Support
• UH
  University Hospitals Birmingham NHS Foundation Trust
• UR
  UK Research and Innovation
• NI
  National Institute for Health and Care Research
• KR
  Kidney Research UK

  Awards: KS_RP_013_20180914, Stoneygate Research Award (KS_RP_20180914)
• UO
  University of Birmingham
• AP
  Astellas Pharma
• SR
  Surgical Reconstruction and Microbiology Research Centre
• BB
  Birmingham Biomedical Research Centre
• NI
  National Institute for Health Research Applied Research Collaboration West
• UP
  UCB Pharma
• DS
  Daiichi Sankyo Europe