Interaction between macrophages and ferroptosis
Central South University · Second Xiangya Hospital of Central South University
Abstract
Ferroptosis, a newly discovered iron-dependent cell death pathway, is characterized by lipid peroxidation and GSH depletion mediated by iron metabolism and is morphologically, biologically and genetically different from other programmed cell deaths. Besides, ferroptosis is usually found accompanied by inflammatory reactions. So far, it has been found participating in the development of many kinds of diseases. Macrophages are a group of immune cells that widely exist in our body for host defense and play an important role in tissue homeostasis by mediating inflammation and regulating iron, lipid and amino acid metabolisms through their unique functions like phagocytosis and efferocytosis, cytokines secretion…
Citation impact
- FWCI
- 48.95
- Percentile
- 100%
- References
- 126
Authors
6- YYYan YangCorresponding
Central South University, Second Xiangya Hospital of Central South University
- YWYu Wang
Central South University, Second Xiangya Hospital of Central South University
- LGLin Guo
Central South University, Second Xiangya Hospital of Central South University
- WGWen Gao
Central South University, Second Xiangya Hospital of Central South University
- TTTing-Li Tang
Central South University, Second Xiangya Hospital of Central South University
Topics & keywords
- Efferocytosis
- Phagocytosis
- Immune system
- Secretion
- Cell biology
- Macrophage
- Inflammation
- Biology
- Good health and well-being