Microemulsions and Nanoemulsions in Skin Drug Delivery
Universidade do Porto · Rede de Química e Tecnologia · +5 more institutions
Abstract
Microemulsions and nanoemulsions are lipid-based pharmaceutical systems with a high potential to increase the permeation of drugs through the skin. Although being isotropic dispersions of two nonmiscible liquids (oil and water), significant differences are encountered between microemulsions and nanoemulsions. Microemulsions are thermodynamically stable o/w emulsions of mean droplet size approximately 100-400 nm, whereas nanoemulsions are thermodynamically unstable o/w emulsions of mean droplet size approximately 1 to 100 nm. Their inner oil phase allows the solubilization of lipophilic drugs, achieving high encapsulation rates, which are instrumental for drug delivery. In this review, the importance of these…
Citation impact
- FWCI
- 21.85
- Percentile
- 100%
- References
- 129
Authors
6- EBEliana B. SoutoCorresponding
Universidade do Porto, Rede de Química e Tecnologia
- ACAmanda Cano
Institut de Nanociència i Nanotecnologia de la Universitat de Barcelona, Universitat de Barcelona
- CMCarlos Martins‐Gomes
University of Trás-os-Montes and Alto Douro
- TETiago E. Coutinho
University of Trás-os-Montes and Alto Douro
- AZAleksandra Zielińska
Institute of Human Genetics, Polish Academy of Sciences
Topics & keywords
- Microemulsion
- Transdermal
- Drug delivery
- Drug
- Permeation
- Nanotechnology
- Chemistry
- Dosage form