Physiological roles of hydrogen sulfide in mammalian cells, tissues, and organs

Over the last two decades, hydrogen sulfide (H 2 S) has emerged as an endogenous regulator of a broad range of physiological functions. H 2 S belongs to the class of molecules known as gasotransmitters, which typically include nitric oxide (NO) and carbon monoxide (CO). Three enzymes are recognized as endogenous sources of H 2 S in various cells and tissues: cystathionine γ-lyase (CSE), cystathionine β-synthase (CBS), and 3-mercaptopyruvate sulfurtransferase (3-MST). The present article reviews the regulation of these enzymes as well as the pathways of their enzymatic and nonenzymatic degradation and elimination. The multiple interactions of H 2 S with other labile endogenous molecules (e.g., NO) and reactive…

• FJ
  Fondation Jérôme Lejeune
• SN
  Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
• MD
  Ministero dell’Istruzione, dell’Università e della Ricerca

  Award: PRIN 201532AHAE
• KS
  Krebsliga Schweiz
• HF
  Hellenic Foundation for Research and Innovation

  Award: HFRI-FM17-886