Targeting TGF-β signal transduction for fibrosis and cancer therapy
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Abstract
Transforming growth factor β (TGF-β) has long been identified with its intensive involvement in early embryonic development and organogenesis, immune supervision, tissue repair, and adult homeostasis. The role of TGF-β in fibrosis and cancer is complex and sometimes even contradictory, exhibiting either inhibitory or promoting effects depending on the stage of the disease. Under pathological conditions, overexpressed TGF-β causes epithelial-mesenchymal transition (EMT), extracellular matrix (ECM) deposition, cancer-associated fibroblast (CAF) formation, which leads to fibrotic disease, and cancer. Given the critical role of TGF-β and its downstream molecules in the progression of fibrosis and cancers,…
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987
total citations
- FWCI
- 75.19
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- 100%
- References
- 228
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Authors
5Topics & keywords
Topics
Keywords
- Cancer research
- Fibrosis
- Biology
- Transforming growth factor
- Carcinogenesis
- Cancer
- Extracellular matrix
- SMAD
UN Sustainable Development Goals
- Good health and well-being
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