CD36, a signaling receptor and fatty acid transporter that regulates immune cell metabolism and fate
Medical College of Wisconsin · Versiti Blood Center of Wisconsin
Abstract
CD36 is a type 2 cell surface scavenger receptor widely expressed in many immune and non-immune cells. It functions as both a signaling receptor responding to DAMPs and PAMPs, as well as a long chain free fatty acid transporter. Recent studies have indicated that CD36 can integrate cell signaling and metabolic pathways through its dual functions and thereby influence immune cell differentiation and activation, and ultimately help determine cell fate. Its expression along with its dual functions in both innate and adaptive immune cells contribute to pathogenesis of common diseases, including atherosclerosis and tumor progression, which makes CD36 and its downstream effectors potential therapeutic targets. This…
Citation impact
- FWCI
- 33.52
- Percentile
- 100%
- References
- 150
Authors
4- YCYiliang ChenCorresponding
Medical College of Wisconsin, Versiti Blood Center of Wisconsin
- JZJue Zhang
Versiti Blood Center of Wisconsin
- WCWeiguo Cui
Medical College of Wisconsin, Versiti Blood Center of Wisconsin
- RLRoy L. SilversteinCorresponding
Medical College of Wisconsin, Versiti Blood Center of Wisconsin
Topics & keywords
- CD36
- Immune system
- Cell biology
- Biology
- Scavenger receptor
- Signal transduction
- Acquired immune system
- Receptor