RNA therapy: rich history, various applications and unlimited future prospects

RNA therapy refers to the treatment or prevention of diseases using RNA-based molecules. The recent advent of a series of effective messenger RNA-based vaccines in response to the COVID-19 pandemic has reignited research interest in RNA therapy. Based on the accumulated results of long-term research in the field of RNA therapy spanning several decades, therapeutic agents for various diseases are being rapidly developed. These therapeutics tend to target diseases that cannot be treated with other conventional drug groups, and several clinical studies are underway for a variety of RNA-based therapeutics against various incurable diseases. This review describes the history of several important discoveries in RNA…

• NR
  National Research Foundation
• NR
  National Research Foundation of Korea

  Awards: NRF-2019R1A4A1028534, 2021R1A2B5B02001501, 2019R1A4A1028534, NRF-2021R1A2B5B02001501
• MO
  Ministry of Science and ICT, South Korea

  Awards: 2019R1A4A1028534, NRF-2021R1A2B5B02001501