articleNature AgingApr 25, 2022HYBRID OA

Biomarker modeling of Alzheimer’s disease using PET-based Braak staging

JTJoseph TherriaultTATharick A. PascoalFZFiroza Z LussierCTCécile TissotMCMira Chamoun

Douglas Mental Health University Institute · Centre Intégré Universitaire de Santé et de Services Sociaux du Saguenay–Lac-Saint-Jean · +11 more institutions

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Abstract

Abstract Gold-standard diagnosis of Alzheimer’s disease (AD) relies on histopathological staging systems. Using the topographical information from [ 18 F]MK6240 tau positron-emission tomography (PET), we applied the Braak tau staging system to 324 living individuals. We used PET-based Braak stage to model the trajectories of amyloid-β, phosphorylated tau (pTau) in cerebrospinal fluid (pTau 181 , pTau 217 , pTau 231 and pTau 235 ) and plasma (pTau 181 and pTau 231 ), neurodegeneration and cognitive symptoms. We identified nonlinear AD biomarker trajectories corresponding to the spatial extent of tau-PET, with modest biomarker changes detectable by Braak stage II and significant changes occurring at stages…

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Topics & keywords

Topics
Keywords
  • Biomarker
  • Neurodegeneration
  • Positron emission tomography
  • Stage (stratigraphy)
  • Pathology
  • Disease
  • Cognitive impairment
  • Alzheimer's disease
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