An unexpected strategy to alleviate hypoxia limitation of photodynamic therapy by biotinylation of photosensitizers
Dalian University of Technology · Dalian University · +3 more institutions
Abstract
The most common working mechanism of photodynamic therapy is based on high-toxicity singlet oxygen, which is called Type II photodynamic therapy. But it is highly dependent on oxygen consumption. Recently, Type I photodynamic therapy has been found to have better hypoxia tolerance to ease this restriction. However, few strategies are available on the design of Type I photosensitizers. We herein report an unexpected strategy to alleviate the limitation of traditional photodynamic therapy by biotinylation of three photosensitizers (two fluorescein-based photosensitizers and the commercially available Protoporphyrin). The three biotiylated photosensitizers named as compound 1, 2 and 3, exhibit impressive ability…
Citation impact
- FWCI
- 17.65
- Percentile
- 100%
- References
- 52
Authors
10- JAJing An
Dalian University of Technology, Dalian University
- STShanliang Tang
Dalian University of Technology, Dalian University
- GHGaobo Hong
Dalian University of Technology, Dalian University
- WCWenlong Chen
Dalian University of Technology, Dalian University
- MCMiaomiao Chen
Dalian University of Technology, Dalian University
Topics & keywords
- Photodynamic therapy
- Biotinylation
- Hypoxia (environmental)
- Photosensitizer
- Chemistry
- Cancer research
- Medicine
- Biochemistry