SARS-CoV-2 infection induces a pro-inflammatory cytokine response through cGAS-STING and NF-κB

SARS-CoV-2 is a novel virus that has rapidly spread, causing a global pandemic. In the majority of infected patients, SARS-CoV-2 leads to mild disease; however, in a significant proportion of infections, individuals develop severe symptoms that can lead to long-lasting lung damage or death. These severe cases are often associated with high levels of pro-inflammatory cytokines and low antiviral responses, which can cause systemic complications. Here, we have evaluated transcriptional and cytokine secretion profiles and detected a distinct upregulation of inflammatory cytokines in infected cell cultures and samples taken from infected patients. Building on these observations, we found a specific activation of…

• DK
  Deutsches Krebsforschungszentrum
• DZ
  Deutsches Zentrum für Infektionsforschung

  Awards: 8029801806, 8029705705, 272983813
• DF
  Deutsche Forschungsgemeinschaft

  Awards: 240245660-SFB 1129, 240245660, 272983813, SFB 1129, BI1693/2-1, TRR 179, BI1693/2, BI1693/1-2
• HA
  Helmholtz Association