reviewSignal Transduction and Targeted TherapyApr 28, 2022GOLD OA

SARS-CoV-2 Omicron variant: recent progress and future perspectives

YFYao FanXLXiang LiLZLei ZhangSWShu WanLZLong Zhang

Sun Yat-sen University · Soochow University · +5 more institutions

PubMed
Indexed incrossrefdoajpubmed

Abstract

Since the outbreak of the coronavirus disease 2019 (COVID-19) pandemic, there have been a few variants of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), one of which is the Omicron variant (B.1.1.529). The Omicron variant is the most mutated SARS-CoV-2 variant, and its high transmissibility and immune evasion ability have raised global concerns. Owing to its enhanced transmissibility, Omicron has rapidly replaced Delta as the dominant variant in several regions. However, recent studies have shown that the Omicron variant exhibits reduced pathogenicity due to altered cell tropism. In addition, Omicron exhibits significant resistance to the neutralizing activity of vaccines, convalescent…

Citation impact

628
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60.48
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100%
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175
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Authors

6

Topics & keywords

Topics
Keywords
  • Transmissibility (structural dynamics)
  • Virology
  • Infectivity
  • Immune system
  • Biology
  • Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
  • Coronavirus disease 2019 (COVID-19)
  • Coronavirus
UN Sustainable Development Goals
  • Good health and well-being
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