Roles of vimentin in health and disease
Northwestern University · Northwestern Medicine · +8 more institutions
Abstract
More than 27 yr ago, the vimentin knockout ( Vim −/− ) mouse was reported to develop and reproduce without an obvious phenotype, implying that this major cytoskeletal protein was nonessential. Subsequently, comprehensive and careful analyses have revealed numerous phenotypes in Vim −/− mice and their organs, tissues, and cells, frequently reflecting altered responses in the recovery of tissues following various insults or injuries. These findings have been supported by cell-based experiments demonstrating that vimentin intermediate filaments (IFs) play a critical role in regulating cell mechanics and are required to coordinate mechanosensing, transduction, signaling pathways, motility, and inflammatory…
Citation impact
- FWCI
- —
- Percentile
- —
- References
- 166
Authors
4- KMKaren M. RidgeCorresponding
Northwestern University, Northwestern Medicine
- JEJohn Eriksson
Åbo Akademi University, University of Turku, Turku Centre for Computer Science, Turku Centre for Biotechnology, Singapore Bioimaging Consortium
- MPMilos Pekny
Florey Institute of Neuroscience and Mental Health, University of Newcastle Australia, University of Gothenburg
- RDRobert D. Goldman
Northwestern University, Northwestern Medicine
Topics & keywords
- Vimentin
- Biology
- Phenotype
- Cytoskeleton
- Cell biology
- Intermediate filament
- Motility
- Knockout mouse
Funding
- ARASCRS Research Foundation
- NUNorthwestern University
- “C“la Caixa” Foundation
- VVINNOVA
- AOAcademy of Finland
- HHjärnfonden
- MEMagnus Ehrnroothin Säätiö
- KGKonung Gustaf V:s och Drottning Victorias Frimurarestiftelse
- SJSigrid Juséliuksen Säätiö
- ÅAÅbo Akademi
- NINational Institutes of HealthAwards: GM096971, AG049665
- HEHORIZON EUROPE Framework Programme
- MRMedical Research Council
- NHNational Heart, Lung, and Blood InstituteAwards: HL128194, HL154998
- NINational Institute of General Medical SciencesAwards: GM096971, AG049665