articleNatureApr 13, 2022HYBRID OA

Somatic mutation rates scale with lifespan across mammals

ACAlex CaganABAdrian Baez‐OrtegaNBNatalia BrzozowskaFAFederico AbascalTCTim Coorens

Wellcome Sanger Institute · Erasmus MC Cancer Institute · +11 more institutions

PubMed
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Abstract

Abstract The rates and patterns of somatic mutation in normal tissues are largely unknown outside of humans 1–7 . Comparative analyses can shed light on the diversity of mutagenesis across species, and on long-standing hypotheses about the evolution of somatic mutation rates and their role in cancer and ageing. Here we performed whole-genome sequencing of 208 intestinal crypts from 56 individuals to study the landscape of somatic mutation across 16 mammalian species. We found that somatic mutagenesis was dominated by seemingly endogenous mutational processes in all species, including 5-methylcytosine deamination and oxidative damage. With some differences, mutational signatures in other species resembled those…

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Topics & keywords

Topics
Keywords
  • Biology
  • Somatic cell
  • Mutation Accumulation
  • Mutation rate
  • Germline mutation
  • Genetics
  • Mutation
  • Mutagenesis
UN Sustainable Development Goals
  • Life in Land
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