Multi-omics single-cell data integration and regulatory inference with graph-linked embedding

Despite the emergence of experimental methods for simultaneous measurement of multiple omics modalities in single cells, most single-cell datasets include only one modality. A major obstacle in integrating omics data from multiple modalities is that different omics layers typically have distinct feature spaces. Here, we propose a computational framework called GLUE (graph-linked unified embedding), which bridges the gap by modeling regulatory interactions across omics layers explicitly. Systematic benchmarking demonstrated that GLUE is more accurate, robust and scalable than state-of-the-art tools for heterogeneous single-cell multi-omics data. We applied GLUE to various challenging tasks, including…

• PU
  Peking University
• S
  Servier
• NK
  National Key Research and Development Program of China

  Award: 2016YFC0901603
• NP
  National Program for Support of Top-notch Young Professionals