Polyunsaturated fatty acids and fatty acid-derived lipid mediators: Recent advances in the understanding of their biosynthesis, structures, and functions

Dyall, Simon C.; Balas, Laurence; Bazán, Nicolás G.; Brenna, J. Thomas; Chiang, Nan; Souza, Felipe da Costa; Dalli, Jesmond; Durand, Thierry; Galano, Jean‐Marie; Lein, Pamela J.; Serhan, Charles N.; Taha, Ameer Y.

doi:10.1016/j.plipres.2022.101165

reviewProgress in Lipid ResearchApr 1, 2022HYBRID OA

Polyunsaturated fatty acids and fatty acid-derived lipid mediators: Recent advances in the understanding of their biosynthesis, structures, and functions

SCSimon C. Dyall LBLaurence Balas NGNicolás G. Bazán JTJ. Thomas Brenna NCNan Chiang

University of Roehampton · Centre National de la Recherche Scientifique · +11 more institutions

PubMed

Indexed incrossrefpubmed

Abstract

Polyunsaturated fatty acids (PUFAs) are structural components of membrane phospholipids, and influence cellular function via effects on membrane properties, and also by acting as a precursor pool for lipid mediators. These lipid mediators are formed via activation of pathways involving at least one step of dioxygen-dependent oxidation, and are consequently called oxylipins. Their biosynthesis can be either enzymatically-dependent, utilising the promiscuous cyclooxygenase, lipoxygenase, or cytochrome P450 mixed function oxidase pathways, or nonenzymatic via free radical-catalyzed pathways. The oxylipins include the classical eicosanoids, comprising prostaglandins, thromboxanes, and leukotrienes, and also more…

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Topics & keywords

Topics

Keywords

Thromboxanes
Polyunsaturated fatty acid
Lipoxygenase
Biochemistry
Lipid signaling
Oxylipin
Biosynthesis
Chemistry

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