Genome-wide analysis of 102,084 migraine cases identifies 123 risk loci and subtype-specific risk alleles

Hautakangas, Heidi; Winsvold, Bendik S.; Ruotsalainen, Sanni; Björnsdóttir, Gyða; Harder, Aster V. E.; Kogelman, Lisette J. A.; Thomas, Laurent F.; Noordam, Raymond; Benner, Christian; Gormley, Padhraig; Artto, Ville; Banasik, Karina; Bjornsdottir, Anna; Boomsma, Dorret I.; Brumpton, Ben; Burgdorf, Kristoffer Sølvsten; Buring, Julie E.; Chalmer, Mona Ameri; Boer, Irene de; Dichgans, Martin; Erikstrup, Christian; Färkkilä, Markus; Garbrielsen, Maiken Elvestad; Ghanbari, Mohsen; Hagen, Knut; Häppölä, Paavo; Hottenga, Jouke‐Jan; Hrafnsdottir, Maria Gudlaug; Hveem, Kristian; Johnsen, Marianne Bakke; Kähönen, Mika; Kristoffersen, Espen Saxhaug; Kurth, Tobias; Lehtimäki, Terho; Lighart, Lannie; Magnússon, Sigurður H.; Malik, Rainer; Pedersen, Ole Birger; Pelzer, Nadine; Penninx, Brenda W.J.H.; Ran, Caroline; Ridker, Paul M.; Rosendaal, Frits R.; Sigurdardottir, Gudrun R.; Skogholt, Anne Heidi; Sveinsson, Ólafur; Thorgeirsson, Thorgeir E.; Ullum, Henrik; Vijfhuizen, Lisanne S.; Widén, Elisabeth; Dijk, Ko Willems van; Boer, Irene de; Maagdenberg, Arn M. J. M. van den; Headache, HUNT All-in; Cohort, Danish Blood Donor Study Genomic; Aromaa, Arpo; Belin, Andrea Carmine; Freilinger, Tobias; Ikram, M. Arfan; Järvelin, Marjo‐Riitta; Raitakari, Olli T.; Terwindt, Gisela M.; Kallela, Mikko; Wessman, Maija; Olesen, Jes; Chasman, Daniel I.; Nyholt, Dale R.; Stefánsson, Hreinn; Stefánsson, Kāri; Maagdenberg, Arn M. J. M. van den; Hansen, Thomas Folkmann; Ripatti, Samuli; Zwart, John‐Anker; Palotie, Aarno; Pirinen, Matti

doi:10.1038/s41588-021-00990-0

reviewNature GeneticsFeb 1, 2022HYBRID OA

Genome-wide analysis of 102,084 migraine cases identifies 123 risk loci and subtype-specific risk alleles

HHHeidi Hautakangas BSBendik S. Winsvold SRSanni Ruotsalainen GBGyða Björnsdóttir AVAster V. E. Harder

University of Helsinki · Institute for Molecular Medicine Finland · +46 more institutions

PubMed

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Abstract

Migraine affects over a billion individuals worldwide but its genetic underpinning remains largely unknown. Here, we performed a genome-wide association study of 102,084 migraine cases and 771,257 controls and identified 123 loci, of which 86 are previously unknown. These loci provide an opportunity to evaluate shared and distinct genetic components in the two main migraine subtypes: migraine with aura and migraine without aura. Stratification of the risk loci using 29,679 cases with subtype information indicated three risk variants that seem specific for migraine with aura (in HMOX2, CACNA1A and MPPED2), two that seem specific for migraine without aura (near SPINK2 and near FECH) and nine that increase…

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Topics & keywords

Topics

Keywords

Migraine
Aura
Migraine with aura
Biology
Genetics
Familial hemiplegic migraine
Cortical spreading depression
Allele

UN Sustainable Development Goals

Good health and well-being

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