reviewApr 1, 2022Closed access

Exposure to per- and Polyfluoroalkyl Substances and Markers of Liver Injury: A Systematic Review and Meta-Analysis

CECostello, Elizabeth,; Rock, Sarah,; Stratakis, Nikos,; Eckel, Sandrah P,; Walker, Douglas I,; Valvi, Damaskini,; Cserbik, Dora,; Jenkins, Todd,; Xanthakos, Stavra A,; Kohli, Rohit,; Sisley, Stephanie,; Vasiliou, Vasilis,; La Merrill, Michele A,; Rosen, Hugo,; Conti, David V,; McConnell, Rob,; Chatzi, Leda,

Abstract

Background

Experimental evidence indicates that exposure to certain pollutants is associated with liver damage. Per- and polyfluoroalkyl substances (PFAS) are persistent synthetic chemicals widely used in industry and consumer products and bioaccumulate in food webs and human tissues, such as the liver.

Objective

The objective of this study was to conduct a systematic review of the literature and meta-analysis evaluating PFAS exposure and evidence of liver injury from rodent and epidemiological studies.

Citation impact

297
total citations
FWCI
—
Percentile
—
References
170
Citations per year

Authors

1
  • CE
    Costello, Elizabeth,; Rock, Sarah,; Stratakis, Nikos,; Eckel, Sandrah P,; Walker, Douglas I,; Valvi, Damaskini,; Cserbik, Dora,; Jenkins, Todd,; Xanthakos, Stavra A,; Kohli, Rohit,; Sisley, Stephanie,; Vasiliou, Vasilis,; La Merrill, Michele A,; Rosen, Hugo,; Conti, David V,; McConnell, Rob,; Chatzi, Leda,Corresponding

Topics & keywords

Topics
Keywords
  • Perfluorooctanoic acid
  • Nonalcoholic fatty liver disease
  • Liver injury
  • Meta-analysis
  • Internal medicine
  • Medicine
  • Steatosis
  • Epidemiology
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