Atherosclerosis: Recent developments
Karolinska University Hospital · Karolinska Institutet · +3 more institutions
Indexed incrossrefpubmed
Abstract
Atherosclerosis is an inflammatory disease of the large arteries that is the major cause of cardiovascular disease (CVD) and stroke. Here, we review the current understanding of the molecular, cellular, genetic, and environmental contributions to atherosclerosis, from both individual pathway and systems perspectives. We place an emphasis on recent developments, some of which have yielded unexpected biology, including previously unknown heterogeneity of inflammatory and smooth muscle cells in atherosclerotic lesions, roles for senescence and clonal hematopoiesis, and links to the gut microbiome.
Citation impact
1,156
total citations
- FWCI
- 87.22
- Percentile
- 100%
- References
- 105
Citations per year
Authors
2Topics & keywords
Topics
Keywords
- Biology
- Disease
- Microbiome
- Inflammation
- Immunology
- Bioinformatics
- Pathology
UN Sustainable Development Goals
- Good health and well-being
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