Dynamic O-GlcNAcylation coordinates ferritinophagy and mitophagy to activate ferroptosis
Nankai University · State Key Laboratory of Medicinal Chemical Biology · +2 more institutions
Abstract
Abstract Ferroptosis is a regulated iron-dependent cell death characterized by the accumulation of lipid peroxidation. A myriad of facets linking amino acid, lipid, redox, and iron metabolisms were found to drive or to suppress the execution of ferroptosis. However, how the cells decipher the diverse pro-ferroptotic stress to activate ferroptosis remains elusive. Here, we report that protein O -GlcNAcylation, the primary nutrient sensor of glucose flux, orchestrates both ferritinophagy and mitophagy for ferroptosis. Following the treatment of ferroptosis stimuli such as RSL3, a commonly used ferroptosis inducer, there exists a biphasic change of protein O -GlcNAcylation to modulate ferroptosis. Pharmacological…
Citation impact
- FWCI
- 35.81
- Percentile
- 100%
- References
- 65
Authors
16- FYFan YuCorresponding
Nankai University, State Key Laboratory of Medicinal Chemical Biology
- QZQianping Zhang
Nankai University, State Key Laboratory of Medicinal Chemical Biology
- HLHanyu Liu
Nankai University, State Key Laboratory of Medicinal Chemical Biology
- JLJinming Liu
Nankai University, State Key Laboratory of Medicinal Chemical Biology
- SYSong Yang
Nankai University, State Key Laboratory of Medicinal Chemical Biology
Topics & keywords
- Mitophagy
- Programmed cell death
- Cell biology
- Mitochondrion
- Chemistry
- Oxidative stress
- Lipid peroxidation
- Inducer