reviewTrends in Pharmacological SciencesMay 3, 2022HYBRID OA

NLRP3 and pyroptosis blockers for treating inflammatory diseases

RCRebecca C. CollKSKate SchroderPPPablo Pelegrı́n

Queen's University Belfast · The University of Queensland · +2 more institutions

PubMed
Indexed incrossrefpubmed

Abstract

Functions in concert with the NLR family, caspase activation and recruitment domain (CARD)containing 4 (NLRC4); (v) absent in melanoma 2 (AIM2); and (vi) Pyrin (PYD) These inflammasome sensor proteins recognize distinct perturbations of homeostasis and form oligomers able to recruit the adaptor protein apoptosis-associated speck-like protein containing a CARD (ASC) into the Glossary Cryopyrin-associated periodic syndromes (CAPS): rare autoinflammatory disorders resulting from gain-of-function mutations in NLRP3 and characterized by periodic fevers, sterile urticaria, and joint inflammation. CAPS incorporate three overlapping disease entities: familial cold autoinflammatory syndrome (FCAS), Muckle-Wells…

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733
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56.82
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100%
References
123
Citations per year

Authors

3

Topics & keywords

Topics
Keywords
  • Pyroptosis
  • Medicine
  • Inflammation
  • Neuroscience
  • Pharmacology
  • Psychology
  • Immunology
  • Inflammasome
UN Sustainable Development Goals
  • Good health and well-being
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