articleeLifeMay 4, 2022GOLD OA

Generation of vascularized brain organoids to study neurovascular interactions

XSXin-Yao SunXJXiang-Chun JuYLYang LiPZPeng-Ming ZengJWJian Wu

ShanghaiTech University · Center for Excellence in Brain Science and Intelligence Technology · +1 more institution

PubMed
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Abstract

Brain organoids have been used to recapitulate the processes of brain development and related diseases. However, the lack of vasculatures, which regulate neurogenesis and brain disorders, limits the utility of brain organoids. In this study, we induced vessel and brain organoids, respectively, and then fused two types of organoids together to obtain vascularized brain organoids. The fused brain organoids were engrafted with robust vascular network-like structures and exhibited increased number of neural progenitors, in line with the possibility that vessels regulate neural development. Fusion organoids also contained functional blood-brain barrier-like structures, as well as microglial cells, a specific…

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Topics & keywords

Topics
Keywords
  • Organoid
  • Neuroscience
  • Neurogenesis
  • Biology
  • Microglia
  • Human brain
  • Neural stem cell
  • Neuroinflammation
UN Sustainable Development Goals
  • Good health and well-being
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