The role of bile acids in carcinogenesis

Abstract Bile acids are soluble derivatives of cholesterol produced in the liver that subsequently undergo bacterial transformation yielding a diverse array of metabolites. The bulk of bile acid synthesis takes place in the liver yielding primary bile acids; however, other tissues have also the capacity to generate bile acids (e.g. ovaries). Hepatic bile acids are then transported to bile and are subsequently released into the intestines. In the large intestine, a fraction of primary bile acids is converted to secondary bile acids by gut bacteria. The majority of the intestinal bile acids undergo reuptake and return to the liver. A small fraction of secondary and primary bile acids remains in the circulation…

• MT
  Magyar Tudományos Akadémia

  Awards: ÚNKP-21-5, POST-COVID2021-33
• JA
  Javna Agencija za Raziskovalno Dejavnost RS

  Award: P1-0390
• DE
  Debreceni Egyetem
• NK
  Nemzeti Kutatási Fejlesztési és Innovációs Hivatal

  Awards: TKP2021, TKP2021-EGA-20, FK128387, ÚNKP-21-5, TKP2021-EGA-19, K123975, TKP2021-EGA
• NK
  Nemzeti Kutatási, Fejlesztési és Innovaciós Alap

  Awards: ÚNKP-21-5, TKP2021-EGA, TKP2021, TKP2021-EGA-20, ÚNKP-21-3-I, ÚNKP-21-3