Interconnections between Inflammageing and Immunosenescence during Ageing

Acute inflammation is a physiological response to injury or infection, with a cascade of steps that ultimately lead to the recruitment of immune cells to clear invading pathogens and heal wounds. However, chronic inflammation arising from the continued presence of the initial trigger, or the dysfunction of signalling and/or effector pathways, is harmful to health. While successful ageing in older adults, including centenarians, is associated with low levels of inflammation, elevated inflammation increases the risk of poor health and death. Hence inflammation has been described as one of seven pillars of ageing. Age-associated sterile, chronic, and low-grade inflammation is commonly termed inflammageing-it is…

• DU
  Diabetes UK
• B
  BIRAX

  Award: 19BX18LCRD
• MR
  Medical Research Council

  Award: MC_PC_14131
• BA
  Biotechnology and Biological Sciences Research Council

  Award: BB/M006727/1
• EA
  Economic and Social Research Council

  Award: ES/G037086/1
• RE
  Research England