KaKs_Calculator 3.0: Calculating Selective Pressure on Coding and Non-Coding Sequences

Abstract KaKs_Calculator 3.0 is an updated toolkit that is capable of calculating selective pressure on both coding and non-coding sequences. Similar to the nonsynonymous/synonymous substitution rate ratio for coding sequences, selection on non-coding sequences can be quantified as the ratio of non-coding nucleotide substitution rate to synonymous substitution rate of adjacent coding sequences. As testified on empirical data, KaKs_Calculator 3.0 shows effectiveness to detect the strength and mode of selection operated on molecular sequences, accordingly demonstrating its great potential to achieve genome-wide scan of natural selection on diverse sequences and identification of potentially functional elements…

• NN
  National Natural Science Foundation of China

  Awards: 32030021, 31871328
• CA
  Chinese Academy of Sciences

  Award: XDA19050302
• NK
  National Key Research and Development Program of China

  Awards: 2017YFC0907502, 153F11KYSB20160008