A genome-wide association study of serum proteins reveals shared loci with common diseases
Icelandic Heart Association · University of Iceland · +3 more institutions
Abstract
With the growing number of genetic association studies, the genotype-phenotype atlas has become increasingly more complex, yet the functional consequences of most disease associated alleles is not understood. The measurement of protein level variation in solid tissues and biofluids integrated with genetic variants offers a path to deeper functional insights. Here we present a large-scale proteogenomic study in 5,368 individuals, revealing 4,035 independent associations between genetic variants and 2,091 serum proteins, of which 36% are previously unreported. The majority of both cis- and trans-acting genetic signals are unique for a single protein, although our results also highlight numerous highly…
Citation impact
- FWCI
- 48.47
- Percentile
- 100%
- References
- 62
Authors
11Topics & keywords
- Genome-wide association study
- Biology
- Phenotype
- Genetics
- Allele
- Genetic association
- Genetic variation
- Genotype