reviewInflammation and RegenerationApr 2, 2022GOLD OA

The roles and mechanisms of senescence-associated secretory phenotype (SASP): can it be controlled by senolysis?

NONaoko Ohtani

Osaka City University

PubMed
Indexed incrossrefdoajpubmed

Abstract

Cellular senescence is a state of irreversible cell cycle arrest that can be induced by a variety of potentially oncogenic stimuli, including DNA damage. Hence, senescence has long been considered to suppress tumorigenesis, acting as a guardian of homeostasis. However, recent studies have revealed that senescent cells exhibit the secretion of a series of inflammatory cytokines, chemokines, growth factors, and matrix remodeling factors that alter the local tissue environment and contribute to chronic inflammation and cancer. This senescence phenotype is termed as senescence-associated secretory phenotype (SASP) and is observed not only in cultured cells in vitro but also in vivo. Recently, the physiological and…

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Topics & keywords

Topics
Keywords
  • Senescence
  • Cell biology
  • Biology
  • Phenotype
  • Chemokine
  • Carcinogenesis
  • DNA damage
  • Inflammation
UN Sustainable Development Goals
  • Good health and well-being
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