reviewFrontiers in ImmunologyApr 7, 2022GOLD OA

Gut Microbiota Interact With the Brain Through Systemic Chronic Inflammation: Implications on Neuroinflammation, Neurodegeneration, and Aging

YMYi MouYDYu DuLZLixing ZhouJYJirong YueXHXianliang Hu

Sichuan University

PubMed
Indexed incrossrefdoajpubmed

Abstract

It has been noticed in recent years that the unfavorable effects of the gut microbiota could exhaust host vigor and life, yet knowledge and theory are just beginning to be established. Increasing documentation suggests that the microbiota-gut-brain axis not only impacts brain cognition and psychiatric symptoms but also precipitates neurodegenerative diseases, such as Alzheimer's disease (AD), Parkinson's disease (PD), and multiple sclerosis (MS). How the blood-brain barrier (BBB), a machinery protecting the central nervous system (CNS) from the systemic circulation, allows the risky factors derived from the gut to be translocated into the brain seems paradoxical. For the unique anatomical, histological, and…

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Authors

11

Topics & keywords

Topics
Keywords
  • Neuroinflammation
  • Neurodegeneration
  • Inflammation
  • Gut flora
  • Gut–brain axis
  • Blood–brain barrier
  • Immune system
  • Intestinal permeability
UN Sustainable Development Goals
  • Good health and well-being
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