Myocardial ischemia/reperfusion injury: Mechanisms of injury and implications for management (Review)
Guangdong Medical College · Sun Yat-sen University · +3 more institutions
Abstract
Myocardial infarction is one of the primary causes of mortality in patients with coronary heart disease worldwide. Early treatment of acute myocardial infarction restores blood supply of ischemic myocardium and decreases the mortality risk. However, when the interrupted myocardial blood supply is recovered within a certain period of time, it causes more serious damage to the original ischemic myocardium; this is known as myocardial ischemia/reperfusion injury (MIRI). The pathophysiological mechanisms leading to MIRI are associated with oxidative stress, intracellular calcium overload, energy metabolism disorder, apoptosis, endoplasmic reticulum stress, autophagy, pyroptosis, necroptosis and ferroptosis. These…
Citation impact
- FWCI
- 31.09
- Percentile
- 100%
- References
- 172
Authors
7- JHJianfeng HeCorresponding
Guangdong Medical College
- DLDanyong Liu
Guangdong Medical College
- LZLixia Zhao
Sun Yat-sen University, Eighth Affiliated Hospital of Sun Yat-sen University
- DZDongcheng Zhou
Guangdong Medical College
- JRJianhui Rong
University of Hong Kong, City University of Hong Kong, Shenzhen Research Institute
Topics & keywords
- Pyroptosis
- Necroptosis
- Autophagy
- Medicine
- Ischemia
- Myocardial infarction
- Reperfusion injury
- Pathophysiology
- Good health and well-being