reviewThe Journal of Experimental MedicineMay 6, 2022HYBRID OA

Neutrophil phenotypes and functions in cancer: A consensus statement

DFDaniela F. QuailBABorko AmulicMAMonowar AzizBBBetsy BarnesEEEvgeniy Eruslanov

McGill University · University of Bristol · +34 more institutions

PubMed
Indexed incrossrefdatacitepubmed

Abstract

Neutrophils are the first responders to infection and inflammation and are thus a critical component of innate immune defense. Understanding the behavior of neutrophils as they act within various inflammatory contexts has provided insights into their role in sterile and infectious diseases; however, the field of neutrophils in cancer is comparatively young. Here, we summarize key concepts and current knowledge gaps related to the diverse roles of neutrophils throughout cancer progression. We discuss sources of neutrophil heterogeneity in cancer and provide recommendations on nomenclature for neutrophil states that are distinct in maturation and activation. We address discrepancies in the literature that…

Citation impact

341
total citations
FWCI
27.51
Percentile
100%
References
307
Citations per year

Authors

25

Topics & keywords

Topics
Keywords
  • Innate immune system
  • Cancer
  • Immunology
  • Biology
  • Inflammation
  • Population
  • Immune system
  • Medicine
UN Sustainable Development Goals
  • Good health and well-being
No related works found for this paper.

Funding