Mesothelial cell-derived antigen-presenting cancer-associated fibroblasts induce expansion of regulatory T cells in pancreatic cancer
Southwestern Medical Center · The University of Texas Southwestern Medical Center · +1 more institution
Abstract
T cells into regulatory T cells (Tregs) in an antigen-specific manner. Moreover, treatment with an antibody targeting the mesothelial cell marker mesothelin can effectively inhibit mesothelial cell to apCAF transition and Treg formation induced by apCAFs. Taken together, our study elucidates how mesothelial cells may contribute to immune evasion in pancreatic cancer and provides insight on strategies to enhance cancer immune therapy.
Citation impact
- FWCI
- 46.07
- Percentile
- 100%
- References
- 55
Authors
13- HHHuocong HuangCorresponding
Southwestern Medical Center, The University of Texas Southwestern Medical Center
- ZWZhaoning Wang
University of California San Diego
- YZYuqing Zhang
Southwestern Medical Center, The University of Texas Southwestern Medical Center
- RPRachana Pradhan
- DGDebolina Ganguly
Southwestern Medical Center, The University of Texas Southwestern Medical Center
Topics & keywords
- Pancreatic cancer
- Cancer research
- Mesothelial Cell
- Mesothelin
- Biology
- Immune system
- Antigen
- Immunology
- Good health and well-being