reviewSignal Transduction and Targeted TherapyMay 10, 2022GOLD OA

Artificial intelligence in cancer target identification and drug discovery

Sichuan University · Friedrich-Alexander-Universität Erlangen-Nürnberg · +8 more institutions

PubMed
Indexed incrossrefdoajpubmed

Abstract

Artificial intelligence is an advanced method to identify novel anticancer targets and discover novel drugs from biology networks because the networks can effectively preserve and quantify the interaction between components of cell systems underlying human diseases such as cancer. Here, we review and discuss how to employ artificial intelligence approaches to identify novel anticancer targets and discover drugs. First, we describe the scope of artificial intelligence biology analysis for novel anticancer target investigations. Second, we review and discuss the basic principles and theory of commonly used network-based and machine learning-based artificial intelligence algorithms. Finally, we showcase the…

Citation impact

410
total citations
FWCI
55.71
Percentile
100%
References
277
Citations per year

Authors

8

Topics & keywords

Keywords
  • Identification (biology)
  • Artificial intelligence
  • Drug discovery
  • Computer science
  • Scope (computer science)
  • Cancer drugs
  • Deep learning
  • Machine learning
UN Sustainable Development Goals
  • Good health and well-being
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