Costimulatory B7-H1 in renal cell carcinoma patients: Indicator of tumor aggressiveness and potential therapeutic target
Mayo Clinic · Johns Hopkins University · +1 more institution
Abstract
Expression of B7-H1, a costimulating glycoprotein in the B7 family, is normally restricted to macrophage-lineage cells, providing a potential costimulatory signal source for regulation of T cell activation. In contrast, aberrant expression of B7-H1 by tumor cells has been implicated in impairment of T cell function and survival, resulting in defective host antitumoral immunity. The relationship between tumor-associated B7-H1 and clinical cancer progression is unknown. Herein, we report B7-H1 expression by both renal cell carcinoma (RCC) tumors of the kidney and RCC tumor-infiltrating lymphocytes. In addition, our analysis of 196 clinical specimens reveals that patients harboring high intratumoral expression…
Citation impact
- FWCI
- 9.11
- Percentile
- 100%
- References
- 49
Authors
15- RHR. Houston ThompsonCorresponding
Mayo Clinic, Johns Hopkins University, Johns Hopkins Medicine
- MDMichael D. Gillett
Mayo Clinic, Johns Hopkins University, Johns Hopkins Medicine
- JCJohn C. Cheville
Mayo Clinic, Johns Hopkins University, Johns Hopkins Medicine
- CMChristine M. Lohse
Mayo Clinic, Johns Hopkins University, Johns Hopkins Medicine
- HDHaidong Dong
Mayo Clinic, Johns Hopkins University, Johns Hopkins Medicine
Topics & keywords
- Renal cell carcinoma
- Immunotherapy
- Cancer
- Tumor progression
- Lymphocyte
- Medicine
- Immunity
- Clear cell renal cell carcinoma
- Good health and well-being