Active scaffolds for on-demand drug and cell delivery
Harvard University · Duke University · +2 more institutions
Abstract
Porous biomaterials have been widely used as scaffolds in tissue engineering and cell-based therapies. The release of biological agents from conventional porous scaffolds is typically governed by molecular diffusion, material degradation, and cell migration, which do not allow for dynamic external regulation. We present a new active porous scaffold that can be remotely controlled by a magnetic field to deliver various biological agents on demand. The active porous scaffold, in the form of a macroporous ferrogel, gives a large deformation and volume change of over 70% under a moderate magnetic field. The deformation and volume variation allows a new mechanism to trigger and enhance the release of various drugs…
Citation impact
- FWCI
- 14.61
- Percentile
- 100%
- References
- 53
Authors
7Topics & keywords
- Scaffold
- Drug delivery
- Tissue engineering
- Porosity
- Chemistry
- Materials science
- Biomedical engineering
- Nanotechnology