articleJournal of Clinical InvestigationJul 15, 2002BRONZE OA

1,25-Dihydroxyvitamin D3 is a negative endocrine regulator of the renin-angiotensin system

YCYan Chun LiJKJuan KongMWMinjie WeiZCZhou‐Feng ChenSQShu Q. Liu

University of Chicago · Washington University in St. Louis · +1 more institution

Indexed incrossrefdoaj

Abstract

Inappropriate activation of the renin-angiotensin system, which plays a central role in the regulation of blood pressure, electrolyte, and volume homeostasis, may represent a major risk factor for hypertension, heart attack, and stroke.Mounting evidence from clinical studies has demonstrated an inverse relationship between circulating vitamin D levels and the blood pressure and/or plasma renin activity, but the mechanism is not understood.We show here that renin expression and plasma angiotensin II production were increased severalfold in vitamin D receptor-null (VDR-null) mice, leading to hypertension, cardiac hypertrophy, and increased water intake.However, the salt-and volume-sensing mechanisms that control…

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Topics & keywords

Topics
Keywords
  • Endocrinology
  • Internal medicine
  • Renin–angiotensin system
  • Homeostasis
  • Calcitriol receptor
  • Angiotensin II
  • Plasma renin activity
  • Vitamin D and neurology
UN Sustainable Development Goals
  • Clean water and sanitation
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