reviewNew England Journal of MedicineMay 6, 2009Closed access

Scleroderma

Marche Polytechnic University · University of Naples Federico II · +3 more institutions

PubMed
Indexed incrossrefpubmed

Abstract

This account of the mechanisms of scleroderma highlights the genetic and molecular changes that cause the vascular changes and fibrosis in the disease. The role of autoantibodies, of which there are several in scleroderma, is unclear. The authors outline a stepwise process that begins with inflammation, reaches its zenith in fibrosis, and ends in atrophy.

Citation impact

1,367
total citations
FWCI
44.30
Percentile
100%
References
93
Citations per year

Authors

3

Topics & keywords

Keywords
  • Medicine
  • Scleroderma (fungus)
  • Fibrosis
  • Autoantibody
  • Pathology
  • Atrophy
  • Dermatology
  • Inflammation
UN Sustainable Development Goals
  • Good health and well-being
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