MicroRNA Signatures in Human Ovarian Cancer

Epithelial ovarian cancer (EOC) is the sixth most common cancer in women worldwide and, despite advances in detection and therapies, it still represents the most lethal gynecologic malignancy in the industrialized countries. Unfortunately, still relatively little is known about the molecular events that lead to the development of this highly aggressive disease. The relatively recent discovery of microRNAs (miRNA), a class of small noncoding RNAs targeting multiple mRNAs and triggering translation repression and/or RNA degradation, has revealed the existence of a new level of gene expression regulation. Multiple studies involving various types of human cancers proved that miRNAs have a causal role in…

• CG
  CLL Global Research Foundation
• AI
  Associazione Italiana per la Ricerca sul Cancro
• FI
  Fondazione Italiana per la Ricerca sul Cancro
• NC
  National Cancer Institute