The Genomic Landscapes of Human Breast and Colorectal Cancers
Howard Hughes Medical Institute · Johns Hopkins University · +6 more institutions
Abstract
Human cancer is caused by the accumulation of mutations in oncogenes and tumor suppressor genes. To catalog the genetic changes that occur during tumorigenesis, we isolated DNA from 11 breast and 11 colorectal tumors and determined the sequences of the genes in the Reference Sequence database in these samples. Based on analysis of exons representing 20,857 transcripts from 18,191 genes, we conclude that the genomic landscapes of breast and colorectal cancers are composed of a handful of commonly mutated gene "mountains" and a much larger number of gene "hills" that are mutated at low frequency. We describe statistical and bioinformatic tools that may help identify mutations with a role in tumorigenesis. These…
Citation impact
- FWCI
- 91.80
- Percentile
- 100%
- References
- 31
Authors
42- LDLaura D. WoodCorresponding
Howard Hughes Medical Institute, Johns Hopkins University, Johns Hopkins Medicine, Sidney Kimmel Cancer Center, Vavilov Institute of General Genetics, St. Joseph Medical Center
- DWD. Williams ParsonsCorresponding
Howard Hughes Medical Institute, Johns Hopkins University, Johns Hopkins Medicine, Sidney Kimmel Cancer Center, Vavilov Institute of General Genetics, St. Joseph Medical Center
- SJSiân JonesCorresponding
Howard Hughes Medical Institute, Johns Hopkins University, Johns Hopkins Medicine, Sidney Kimmel Cancer Center, Vavilov Institute of General Genetics, St. Joseph Medical Center
- JLJimmy LinCorresponding
Howard Hughes Medical Institute, Johns Hopkins University, Johns Hopkins Medicine, Sidney Kimmel Cancer Center, Vavilov Institute of General Genetics, St. Joseph Medical Center
- TSTobias SjöblomCorresponding
Howard Hughes Medical Institute, Johns Hopkins University, Johns Hopkins Medicine, Sidney Kimmel Cancer Center, Vavilov Institute of General Genetics, St. Joseph Medical Center
Topics & keywords
- Carcinogenesis
- Gene
- Biology
- Exon
- Genomics
- Colorectal cancer
- Breast cancer
- Genetics
- Good health and well-being