Multi-Institutional Phase I/II Trial of Stereotactic Body Radiation Therapy for Liver Metastases
University of Colorado Cancer Center · Indiana University – Purdue University Indianapolis · +1 more institution
Abstract
Purpose To evaluate the efficacy and tolerability of high-dose stereotactic body radiation therapy (SBRT) for the treatment of patients with one to three hepatic metastases. Patients and Methods Patients with one to three hepatic lesions and maximum individual tumor diameters less than 6 cm were enrolled and treated on a multi-institutional, phase I/II clinical trial in which they received SBRT delivered in three fractions. During phase I, the total dose was safely escalated from 36 Gy to 60 Gy. The phase II dose was 60 Gy. The primary end point was local control. Lesions with at least 6 months of radiographic follow-up were considered assessable for local control. Secondary end points were toxicity and…
Citation impact
- FWCI
- 58.88
- Percentile
- 100%
- References
- 25
Authors
12- KEKyle E. RusthovenCorresponding
University of Colorado Cancer Center, Indiana University – Purdue University Indianapolis, University of Colorado Denver
- BDBrian D. Kavanagh
University of Colorado Cancer Center, Indiana University – Purdue University Indianapolis, University of Colorado Denver
- HRHiginia R. Cárdenes
University of Colorado Cancer Center, Indiana University – Purdue University Indianapolis, University of Colorado Denver
- VWVolker W. Stieber
University of Colorado Cancer Center, Indiana University – Purdue University Indianapolis, University of Colorado Denver
- SHStuart H. Burri
University of Colorado Cancer Center, Indiana University – Purdue University Indianapolis, University of Colorado Denver
Topics & keywords
- Medicine
- Radiation therapy
- Oncology
- Internal medicine
- Radiology
- Good health and well-being