The Consensus Coding Sequences of Human Breast and Colorectal Cancers
University of South Carolina · University Hospitals of Cleveland · +3 more institutions
Abstract
The elucidation of the human genome sequence has made it possible to identify genetic alterations in cancers in unprecedented detail. To begin a systematic analysis of such alterations, we determined the sequence of well-annotated human protein-coding genes in two common tumor types. Analysis of 13,023 genes in 11 breast and 11 colorectal cancers revealed that individual tumors accumulate an average of ∼90 mutant genes but that only a subset of these contribute to the neoplastic process. Using stringent criteria to delineate this subset, we identified 189 genes (average of 11 per tumor) that were mutated at significant frequency. The vast majority of these genes were not known to be genetically altered in…
Citation impact
- FWCI
- 150.44
- Percentile
- 100%
- References
- 36
Authors
29- TSTobias SjöblomCorresponding
University of South Carolina, University Hospitals of Cleveland, Sidney Kimmel Comprehensive Cancer Center, The University of Texas Southwestern Medical Center
- SJSiân JonesCorresponding
University of South Carolina, University Hospitals of Cleveland, Sidney Kimmel Comprehensive Cancer Center, The University of Texas Southwestern Medical Center
- LDLaura D. WoodCorresponding
University of South Carolina, University Hospitals of Cleveland, Sidney Kimmel Comprehensive Cancer Center, The University of Texas Southwestern Medical Center
- DWD. Williams ParsonsCorresponding
University of South Carolina, University Hospitals of Cleveland, Sidney Kimmel Comprehensive Cancer Center, The University of Texas Southwestern Medical Center
- JLJimmy Lin
University of South Carolina, University Hospitals of Cleveland, Sidney Kimmel Comprehensive Cancer Center, The University of Texas Southwestern Medical Center
Topics & keywords
- Biology
- Gene
- Human genome
- Genome
- Genetics
- KRAS
- Breast cancer
- Computational biology
- Good health and well-being