Abstract
The current state of knowledge on how copper metallochaperones support the maturation of cuproproteins is reviewed. Copper is needed within mitochondria to supply the Cu(A) and intramembrane Cu(B) sites of cytochrome oxidase, within the trans-Golgi network to supply secreted cuproproteins and within the cytosol to supply superoxide dismutase 1 (Sod1). Subpopulations of copper-zinc superoxide dismutase also localize to mitochondria, the secretory system, the nucleus and, in plants, the chloroplast, which also requires copper for plastocyanin. Prokaryotic cuproproteins are found in the cell membrane and in the periplasm of gram-negative bacteria. Cu(I) and Cu(II) form tight complexes with organic molecules and…
Citation impact
703
total citations
- FWCI
- 31.51
- Percentile
- 100%
- References
- 147
Citations per year
Authors
2Topics & keywords
Topics
Keywords
- Periplasmic space
- Copper
- Plastocyanin
- Chemistry
- Superoxide dismutase
- Biochemistry
- Cytosol
- Golgi apparatus
No related works found for this paper.