Selective depletion of macrophages reveals distinct, opposing roles during liver injury and repair
Brigham and Women's Hospital · Centre for Inflammation Research · +7 more institutions
Abstract
Macrophages perform both injury-inducing and repair-promoting tasks in different models of inflammation, leading to a model of macrophage function in which distinct patterns of activation have been proposed. We investigated macrophage function mechanistically in a reversible model of liver injury in which the injury and recovery phases are distinct. Carbon tetrachloride-induced liver fibrosis revealed scar-associated macrophages that persisted throughout recovery. A transgenic mouse (CD11b-DTR) was generated in which macrophages could be selectively depleted. Macrophage depletion when liver fibrosis was advanced resulted in reduced scarring and fewer myofibroblasts. Macrophage depletion during recovery, by…
Citation impact
- FWCI
- 24.98
- Percentile
- 100%
- References
- 45
Authors
9- JSJeremy S. DuffieldCorresponding
Brigham and Women's Hospital, Centre for Inflammation Research, Medical Research Council, University of Edinburgh
- SJStuart J. Forbes
St Mary's Hospital
- CMChristothea M. Constandinou
Centre for Inflammation Research
- SCSpike Clay
Centre for Inflammation Research, Medical Research Council, University of Edinburgh
- MPMarina Partolina
New York University
Topics & keywords
- Macrophage
- Fibrosis
- Inflammation
- Myofibroblast
- Liver injury
- Cell biology
- Integrin alpha M
- Cancer research
- Good health and well-being