Multivascular networks and functional intravascular topologies within biocompatible hydrogels
Rice University · University of Washington · +3 more institutions
Abstract
Solid organs transport fluids through distinct vascular networks that are biophysically and biochemically entangled, creating complex three-dimensional (3D) transport regimes that have remained difficult to produce and study. We establish intravascular and multivascular design freedoms with photopolymerizable hydrogels by using food dye additives as biocompatible yet potent photoabsorbers for projection stereolithography. We demonstrate monolithic transparent hydrogels, produced in minutes, comprising efficient intravascular 3D fluid mixers and functional bicuspid valves. We further elaborate entangled vascular networks from space-filling mathematical topologies and explore the oxygenation and flow of human…
Citation impact
- FWCI
- 70.86
- Percentile
- 100%
- References
- 66
Authors
17Topics & keywords
- Self-healing hydrogels
- Biocompatible material
- Extravasation
- Computer science
- Nanotechnology
- Biomedical engineering
- Materials science
- Chemistry
Funding
- NSNational Science FoundationAwards: 1728239, 1450681, 1250104
- RURice University
- RJRobert J. Kleberg, Jr. and Helen C. Kleberg Foundation
- NINational Institutes of HealthAwards: DP5OD019876, T32EB001650, T32GM095421, DP2HL137188, F31 NRSA, 1450681
- NHNational Heart, Lung, and Blood InstituteAwards: DP2HL137188, HL134295
- NONIH Office of the DirectorAward: DP5OD019876
- NINational Institute of General Medical SciencesAward: T32GM095421
- NINational Institute of Biomedical Imaging and BioengineeringAward: T32EB001650