preprintWellcome Open ResearchNov 26, 2019GOLD OA

Guidelines for performing Mendelian randomization investigations

SBStephen BurgessGDGeorge Davey SmithNMNeil M DaviesFDFrank DudbridgeDGDipender Gill

University of Cambridge · MRC Biostatistics Unit · +9 more institutions

Indexed incrossrefdoaj

Abstract

This paper provides guidelines for performing Mendelian randomization investigations. It is aimed at practitioners seeking to undertake analyses and write up their findings, and at journal editors and reviewers seeking to assess Mendelian randomization manuscripts. The guidelines are divided into nine sections: motivation and scope, data sources, choice of genetic variants, variant harmonization, primary analysis, supplementary and sensitivity analyses (one section on robust methods and one on other approaches), data presentation, and interpretation. These guidelines will be updated based on feedback from the community and advances in the field. Updates will be made periodically as needed, and at least every…

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Authors

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Topics & keywords

Topics
Keywords
  • Mendelian randomization
  • Harmonization
  • Scope (computer science)
  • Presentation (obstetrics)
  • Computer science
  • Mendelian inheritance
  • Psychology
  • Medicine
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