articleJournal of the American Chemical SocietyOct 28, 2005Closed access

Ruthenium-Catalyzed Cycloaddition of Alkynes and Organic Azides

Scripps Research Institute · Hong Kong University of Science and Technology · +1 more institution

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Abstract

Cp*RuCl(PPh3)2 is an effective catalyst for the regioselective "fusion" of organic azides and terminal alkynes, producing 1,5-disubstituted 1,2,3-triazoles. Internal alkynes also participate in this catalysis, resulting in fully substituted 1,2,3-triazoles.

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