Acute inflammatory response via neutrophil activation protects against the development of chronic pain
McGill University Health Centre · McGill University · +9 more institutions
Abstract
The transition from acute to chronic pain is critically important but not well understood. Here, we investigated the pathophysiological mechanisms underlying the transition from acute to chronic low back pain (LBP) and performed transcriptome-wide analysis in peripheral immune cells of 98 participants with acute LBP, followed for 3 months. Transcriptomic changes were compared between patients whose LBP was resolved at 3 months with those whose LBP persisted. We found thousands of dynamic transcriptional changes over 3 months in LBP participants with resolved pain but none in those with persistent pain. Transient neutrophil-driven up-regulation of inflammatory responses was protective against the transition to…
Citation impact
- FWCI
- 35.40
- Percentile
- 100%
- References
- 68
Authors
20Topics & keywords
- Medicine
- Inflammation
- Analgesic
- Chronic pain
- Immune system
- Acute pain
- Peripheral
- Transcriptome
- Good health and well-being